CLINDAMYCIN

Structure/Class
  1. A chlorine substitute of lincomycin (it does not contain the macrocyclic lactone ring associated with macrolides)
Pharmacodynamics
  1. Binds to the 50S ribosomal subunit.
  2. Effective against Gram+ve bacteria and anaerobes (both Gram+ve and Gram-ve). It does not have activity against aerobic Gram-ve bacteria due to the presence of the cell wall.
    • It is effective against staph, strep and pneumococci, but enterococcus is resistant to clindamycin.
    • Therefore, indications for clindamycin are as follows:
      1. Skin infections
      2. Anaerobic infections
      3. May be used to treat GIT infections or PID.
  3. Note that resistance to clindamycin will confer cross resistance to macrolides. Resistance is due to:
    • Mutation of ribosomal receptor site
    • Modification of receptor site by methylase
    • Enzymatic inactivation.
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